Perfectly situated on one of the most coveted streets in Woodland Hills-South, 22505 Macfarlane offers the ultimate in privacy, exclusivity, and high-end family living. This stunning trophy home sits on an expansive 17,234 square foot lot and has spectacular panoramic jetliner views from almost everywhere on the property. The interior is an architectural masterpiece that seamlessly blends mid-century charm with modern amenities. Walls of glass frame showcase breathtaking valley views as far as the eye can see, while the open floor plan, stunning wood beamed ceilings, a recently remodeled gourmet chef’s kitchen, and custom expensive finishes throughout create a happy, bright and inviting atmosphere. The single-level main residence features three spacious bedrooms and three bathrooms, including an oversized primary suite with soaring ceilings, dual walk-in closets, and a spa-like en-suite bathroom. But the magic doesn’t stop there! This exceptional property also includes a luxurious 396 square foot updated ADU with its own entrance and outdoor living area. The grounds are simply magnificent and include a picturesque entertainer's yard, massive swimmers dream pool, pickleball court, romantic sitting areas, sprawling grassy areas, lush landscaping, mature citrus trees, a charming bonus cottage, and spectacular sweeping breathtaking views of the San Fernando Valley. You will find yourself in awe of the epic daily sunsets, ever present wildlife, and complete serenity enjoyed from the yard. The amenities could not be better with The Calabasas Commons, The Topanga Village, Gelson’s, Whole Foods, famous restaurants, endless hiking trails, and the 101 freeway just minutes from the front door. Don’t miss this rare opportunity to own a Woodland Hills treasure!